Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection

During chronic HIV infection, viral replication is concentrated in secondary lymphoid follicles. Cytotoxic CD8 T cells control HIV replication in extrafollicular regions, but not in the follicle. Here, we show CXCR5(hi)CD44(hi)CD8 T cells are a regulatory subset differing from conventional CD8 T cel...

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發表在:PLoS Pathog
Main Authors: Miles, Brodie, Miller, Shannon M., Folkvord, Joy M., Levy, David N., Rakasz, Eva G., Skinner, Pamela J., Connick, Elizabeth
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055335/
https://ncbi.nlm.nih.gov/pubmed/27716848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005924
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