Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer′s and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies

α-Synuclein (αSyn) is a major constituent of proteinaceous aggregates in neurodegenerative diseases such as Parkinson′s disease (PD) and a potential biomarker candidate for diagnosis and treatment effects. However, studies about αSyn in cerebrospinal fluid (CSF) in diseases are inconsistent and main...

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Bibliographic Details
Published in:Mol Cell Proteomics
Main Authors: Oeckl, Patrick, Metzger, Fabian, Nagl, Magdalena, von Arnim, Christine A.F., Halbgebauer, Steffen, Steinacker, Petra, Ludolph, Albert C., Otto, Markus
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054339/
https://ncbi.nlm.nih.gov/pubmed/27507836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.059915
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