Reduction of Isoagglutinin in Intravenous Immunoglobulin (IVIG) Using Blood Group A- and B-Specific Immunoaffinity Chromatography: Industry-Scale Assessment

BACKGROUND: Hemolysis, a rare but potentially serious complication of intravenous immunoglobulin (IVIG) therapy, is associated with the presence of antibodies to blood groups A and B (isoagglutinins) in the IVIG product. An immunoaffinity chromatography (IAC) step in the production process could dec...

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Detalhes bibliográficos
Publicado no:BioDrugs
Main Authors: Gerber, Simon, Gaida, Annette, Spiegl, Nicole, Wymann, Sandra, Antunes, Adriano Marques, Menyawi, Ibrahim El, Zurbriggen, Brigitte, Hubsch, Alphonse, Imboden, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054059/
https://ncbi.nlm.nih.gov/pubmed/27646589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40259-016-0192-3
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