Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes

Osteocytes comprising over 90% of the bone cell population are highly susceptible to the adverse effects of glucocorticoids (GC) administration. Here we observed that Dexamethasone (Dex) induces a robust cytoskeleton rearrangement and decreases Cx43 protein expression in osteocyte-like MLO-Y4 cells....

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Gao, Junjie, Cheng, Tak Sum, Qin, An, Pavlos, Nathan J., Wang, Tao, Song, Kai, Wang, Yan, Chen, Lianzhi, Zhou, Lin, Jiang, Qing, Takayanagi, Hiroshi, Yan, Sheng, Zheng, Minghao
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper: Gerotarget (Focus on Aging)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053625/
https://ncbi.nlm.nih.gov/pubmed/27127181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9034
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