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Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-like transmission of protein aggregation. Factors responsible for the initiation of AS aggregation are unknown. To evaluate the role of amyloid proteins made by the microbiota we exposed aged rats and transgen...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Chen, Shu G., Stribinskis, Vilius, Rane, Madhavi J., Demuth, Donald R., Gozal, Evelyne, Roberts, Andrew M., Jagadapillai, Rekha, Liu, Ruolan, Choe, Kyonghwan, Shivakumar, Bhooma, Son, Francheska, Jin, Shunying, Kerber, Richard, Adame, Anthony, Masliah, Eliezer, Friedland, Robert P.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052651/
https://ncbi.nlm.nih.gov/pubmed/27708338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34477
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