Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-like transmission of protein aggregation. Factors responsible for the initiation of AS aggregation are unknown. To evaluate the role of amyloid proteins made by the microbiota we exposed aged rats and transgen...

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Publicat a:Sci Rep
Autors principals: Chen, Shu G., Stribinskis, Vilius, Rane, Madhavi J., Demuth, Donald R., Gozal, Evelyne, Roberts, Andrew M., Jagadapillai, Rekha, Liu, Ruolan, Choe, Kyonghwan, Shivakumar, Bhooma, Son, Francheska, Jin, Shunying, Kerber, Richard, Adame, Anthony, Masliah, Eliezer, Friedland, Robert P.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052651/
https://ncbi.nlm.nih.gov/pubmed/27708338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34477
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