Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-like transmission of protein aggregation. Factors responsible for the initiation of AS aggregation are unknown. To evaluate the role of amyloid proteins made by the microbiota we exposed aged rats and transgen...

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Udgivet i:Sci Rep
Main Authors: Chen, Shu G., Stribinskis, Vilius, Rane, Madhavi J., Demuth, Donald R., Gozal, Evelyne, Roberts, Andrew M., Jagadapillai, Rekha, Liu, Ruolan, Choe, Kyonghwan, Shivakumar, Bhooma, Son, Francheska, Jin, Shunying, Kerber, Richard, Adame, Anthony, Masliah, Eliezer, Friedland, Robert P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052651/
https://ncbi.nlm.nih.gov/pubmed/27708338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34477
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