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The Important Role of Halogen Bond in Substrate Selectivity of Enzymatic Catalysis
The use of halogen bond is widespread in drug discovery, design, and clinical trials, but is overlooked in drug biosynthesis. Here, the role of halogen bond in the nitrilase-catalyzed synthesis of ortho-, meta-, and para-chlorophenylacetic acid was investigated. Different distributions of halogen bo...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5052520/ https://ncbi.nlm.nih.gov/pubmed/27708371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34750 |
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