A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor

G protein-coupled receptors (GPCRs) mediate many signal transduction processes in the body. The discovery that these receptors are voltage-sensitive has changed our understanding of their behavior. The M2 muscarinic acetylcholine receptor (M2R) was found to exhibit depolarization-induced charge move...

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Bibliografski detalji
Izdano u:Biophys J
Glavni autori: Barchad-Avitzur, Ofra, Priest, Michael F., Dekel, Noa, Bezanilla, Francisco, Parnas, Hanna, Ben-Chaim, Yair
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2016
Teme:
Channels and Transporters
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052511/
https://ncbi.nlm.nih.gov/pubmed/27705763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.08.035
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