TNFα is required for cholestasis-induced liver fibrosis in the mouse

TNFα, a mediator of hepatotoxicity in several animal models, is elevated in acute and chronic liver diseases. Therefore, we investigated whether hepatic injury and fibrosis due to bile duct ligation (BDL) would be reduced in TNFα knockout mice (TNFα−/−). Survival after BDL was 60% in wild-type mice...

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Bibliografiska uppgifter
I publikationen:Biochem Biophys Res Commun
Huvudupphovsmän: Gäbele, Erwin, Froh, Matthias, Arteel, Gavin E., Uesugi, Takehiko, Hellerbrand, Claus, Schölmerich, Jürgen, Brenner, David A., Thurman, Ronald G., Rippe, Richard A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052129/
https://ncbi.nlm.nih.gov/pubmed/18996089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.10.155
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