TNFα is required for cholestasis-induced liver fibrosis in the mouse

TNFα, a mediator of hepatotoxicity in several animal models, is elevated in acute and chronic liver diseases. Therefore, we investigated whether hepatic injury and fibrosis due to bile duct ligation (BDL) would be reduced in TNFα knockout mice (TNFα−/−). Survival after BDL was 60% in wild-type mice...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Gäbele, Erwin, Froh, Matthias, Arteel, Gavin E., Uesugi, Takehiko, Hellerbrand, Claus, Schölmerich, Jürgen, Brenner, David A., Thurman, Ronald G., Rippe, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052129/
https://ncbi.nlm.nih.gov/pubmed/18996089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.10.155
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