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NGS-based reverse genetic screen for common embryonic lethal mutations compromising fertility in livestock

We herein report the result of a large-scale, next generation sequencing (NGS)-based screen for embryonic lethal (EL) mutations in Belgian beef and New Zealand dairy cattle. We estimated by simulation that cattle might carry, on average, ∼0.5 recessive EL mutations. We mined exome sequence data from...

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Bibliografiske detaljer
Udgivet i:Genome Res
Main Authors: Charlier, Carole, Li, Wanbo, Harland, Chad, Littlejohn, Mathew, Coppieters, Wouter, Creagh, Frances, Davis, Steve, Druet, Tom, Faux, Pierre, Guillaume, François, Karim, Latifa, Keehan, Mike, Kadri, Naveen Kumar, Tamma, Nico, Spelman, Richard, Georges, Michel
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052051/
https://ncbi.nlm.nih.gov/pubmed/27646536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.207076.116
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