Paracrine Effects of Adipose-Derived Stem Cells on Matrix Stiffness-Induced Cardiac Myofibroblast Differentiation via Angiotensin II Type 1 Receptor and Smad7

Human mesenchymal stem cells (hMSCs) hold great promise in cardiac fibrosis therapy, due to their potential ability of inhibiting cardiac myofibroblast differentiation (a hallmark of cardiac fibrosis). However, the mechanism involved in their effects remains elusive. To explore this, it is necessary...

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Pubblicato in:Sci Rep
Autori principali: Yong, Kar Wey, Li, Yuhui, Liu, Fusheng, Bin Gao, Lu, Tian Jian, Wan Abas, Wan Abu Bakar, Wan Safwani, Wan Kamarul Zaman, Pingguan-Murphy, Belinda, Ma, Yufei, Xu, Feng, Huang, Guoyou
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050447/
https://ncbi.nlm.nih.gov/pubmed/27703175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33067
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