Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants

BACKGROUND: Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear. METHODS: We infected a panel of 30 inbred strain...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: High, Monica, Cho, Hye-Youn, Marzec, Jacqui, Wiltshire, Tim, Verhein, Kirsten C., Caballero, Mauricio T., Acosta, Patricio L., Ciencewicki, Jonathan, McCaw, Zackary R., Kobzik, Lester, Miller-DeGraff, Laura, Gladwell, Wes, Peden, David B., Serra, M. Elina, Shi, Min, Weinberg, Clarice, Suzuki, Oscar, Wang, Xuting, Bell, Douglas A., Polack, Fernando P., Kleeberger, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5049919/
https://ncbi.nlm.nih.gov/pubmed/27554839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.08.011
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