Intratumoral accumulation of podoplanin-expressing lymph node stromal cells promote tumor growth through elimination of CD4(+) tumor-infiltrating lymphocytes

The beneficial effects of checkpoint blockade in tumor immunotherapy are limited to patients with increased tumor-infiltrating lymphocytes (TILs). Delineation of the regulatory networks that orchestrate the presence of TILs holds great promise for the design of effective immunotherapies. Podoplanin/...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Hatzioannou, Aikaterini, Nayar, Saba, Gaitanis, Anastasios, Barone, Francesca, Anagnostopoulos, Constantinos, Verginis, Panayotis
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048774/
https://ncbi.nlm.nih.gov/pubmed/27757315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1216289
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