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Targeting Akt in cell transfer immunotherapy for cancer

Pharmacologic inhibitors of the serine/threonine kinase Akt, initially aimed at deranged oncogenic pathways in tumors, have recently been shown to act as immunomodulators that markedly enhance the antitumor properties of T cells. Repurposing Akt inhibitors to improve antitumor immunity may be viewed...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Crompton, Joseph G, Sukumar, Madhusudhanan, Restifo, Nicholas P
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048755/
https://ncbi.nlm.nih.gov/pubmed/27757294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1014776
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