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Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome

A novel rat model for a well-characterized human mitochondrial disease, mitochondrial DNA depletion syndrome with associated deoxyguanosine kinase (DGUOK) deficiency, is described. The rat model recapitulates the pathologic and biochemical signatures of the human disease. The application of electron...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Free Radic Biol Med
मुख्य लेखकों: Bennett, Brian, Helbling, Daniel, Meng, Hui, Jarzembowski, Jason, Geurts, Aron M., Friederich, Marisa W., Van Hove, Johan L. K., Lawlor, Michael W., Dimmock, David P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047058/
https://ncbi.nlm.nih.gov/pubmed/26773591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.01.001
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