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Population pharmacokinetic and pharmacodynamic analyses of safinamide in subjects with Parkinson's disease

Safinamide is an orally administered α‐aminoamide derivative with both dopaminergic and non‐dopaminergic properties. Nonlinear mixed effects models for population pharmacokinetic (PK) and pharmacokinetic–pharmacodynamic (PKPD) analyses were developed using records from, respectively, 623 and 668 pat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pharmacol Res Perspect
Prif Awduron: Loprete, Luca, Leuratti, Chiara, Cattaneo, Carlo, Thapar, Mita M., Farrell, Colm, Sardina, Marco
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045937/
https://ncbi.nlm.nih.gov/pubmed/27713822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.251
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