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Population pharmacokinetic and pharmacodynamic analyses of safinamide in subjects with Parkinson's disease

Safinamide is an orally administered α‐aminoamide derivative with both dopaminergic and non‐dopaminergic properties. Nonlinear mixed effects models for population pharmacokinetic (PK) and pharmacokinetic–pharmacodynamic (PKPD) analyses were developed using records from, respectively, 623 and 668 pat...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Loprete, Luca, Leuratti, Chiara, Cattaneo, Carlo, Thapar, Mita M., Farrell, Colm, Sardina, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045937/
https://ncbi.nlm.nih.gov/pubmed/27713822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.251
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