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Population pharmacokinetic and pharmacodynamic analyses of safinamide in subjects with Parkinson's disease

Safinamide is an orally administered α‐aminoamide derivative with both dopaminergic and non‐dopaminergic properties. Nonlinear mixed effects models for population pharmacokinetic (PK) and pharmacokinetic–pharmacodynamic (PKPD) analyses were developed using records from, respectively, 623 and 668 pat...

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Bibliografische gegevens
Gepubliceerd in:Pharmacol Res Perspect
Hoofdauteurs: Loprete, Luca, Leuratti, Chiara, Cattaneo, Carlo, Thapar, Mita M., Farrell, Colm, Sardina, Marco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045937/
https://ncbi.nlm.nih.gov/pubmed/27713822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.251
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