Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure

RATIONALE: Disruption in subcellular targeting of Ca(2+) signaling complexes secondary to changes in cardiac myocyte structure may contribute to the pathophysiology of a variety of cardiac diseases, including heart failure (HF) and certain arrhythmias. OBJECTIVE: To explore microdomain-targeted remo...

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Publicado en:Circ Res
Autores principales: Sanchez-Alonso, Jose L., Bhargava, Anamika, O’Hara, Thomas, Glukhov, Alexey V., Schobesberger, Sophie, Bhogal, Navneet, Sikkel, Markus B., Mansfield, Catherine, Korchev, Yuri E., Lyon, Alexander R., Punjabi, Prakash P., Nikolaev, Viacheslav O., Trayanova, Natalia A., Gorelik, Julia
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Cellular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045818/
https://ncbi.nlm.nih.gov/pubmed/27572487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.308698
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