SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis

SIRT1 is a multifaceted NAD(+)-dependent protein deacetylase known to act as a tumor promoter or suppressor in different cancers. Here, we describe a novel mechanism of SIRT1-induced hepatocellular carcinoma (HCC) metastasis. SIRT1 overexpression was frequently detected in human HCC specimens and wa...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Li, Yuming, Xu, Shangcheng, Li, Jing, Zheng, Lu, Feng, Min, Wang, Xiaoya, Han, Keqiang, Pi, Huifeng, Li, Min, Huang, Xiaobing, You, Nan, Tian, Yewang, Zuo, Guohua, Li, Hongyan, Zhao, Hongzhi, Deng, Ping, Yu, Zhengping, Zhou, Zhou, Liang, Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045394/
https://ncbi.nlm.nih.gov/pubmed/27081083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8711
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