Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells

The cinobufagin (CB) has a broad spectrum of cytotoxicity to inhibit cell proliferation of various human cancer cell lines, but the molecular mechanisms still remain elusive. Here we observed that CB inhibited the cell proliferation and tumor growth, but induced cell cycle arrest and apoptosis in a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Guangxin, Wang, Chao, Sun, Mei, Li, Jindong, Wang, Bin, Jin, Chengyan, Hua, Peiyan, Song, Ge, Zhang, Yifan, Nguyen, Lisa L.H., Cui, Ranji, Liu, Runhua, Wang, Lizhong, Zhang, Xingyi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045368/
https://ncbi.nlm.nih.gov/pubmed/26959116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7898
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