Novel Acylguanidine-Based Inhibitor of HIV-1

The emergence of transmissible HIV-1 strains with resistance to antiretroviral drugs highlights a continual need for new therapies. Here we describe a novel acylguanidine-containing compound, 1-(2-(azepan-1-yl)nicotinoyl)guanidine (or SM111), that inhibits in vitro replication of HIV-1, including st...

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Vydáno v:J Virol
Hlavní autoři: Mwimanzi, Philip, Tietjen, Ian, Miller, Scott C., Shahid, Aniqa, Cobarrubias, Kyle, Kinloch, Natalie N., Baraki, Bemuluyigza, Richard, Jonathan, Finzi, Andrés, Fedida, David, Brumme, Zabrina L., Brockman, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5044834/
https://ncbi.nlm.nih.gov/pubmed/27512074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01107-16
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