Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression

Small heterodimer partner (SHP) is a transcriptional corepressor regulating diverse metabolic processes. Here, we show that SHP acts as an intrinsic negative regulator of iron homeostasis. SHP-deficient mice maintained on a high-iron diet showed increased serum hepcidin levels, decreased expression...

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Udgivet i:Sci Rep
Main Authors: Kim, Don-Kyu, Kim, Yong-Hoon, Jung, Yoon Seok, Kim, Ki-Sun, Jeong, Jae-Ho, Lee, Yong-Soo, Yuk, Jae-Min, Oh, Byung-Chul, Choy, Hyon E., Dooley, Steven, Muckenthaler, Martina U., Lee, Chul-Ho, Choi, Hueng-Sik
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043349/
https://ncbi.nlm.nih.gov/pubmed/27688041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34630
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