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Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III.

The introduction of a replication-inhibiting lesion into the DNA of Escherichia coli generates the induced, multigene SOS response. One component of the SOS response is a marked increase in mutation rate, dependent on RecA protein and the induced mutagenesis proteins UmuC and UmuD. A variety of prev...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rajagopalan, M, Lu, C, Woodgate, R, O'Donnell, M, Goodman, M F, Echols, H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50425/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438275/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.22.10777
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