Evaluation of Resistance-Associated Substitutions in NS5A Using Direct Sequence and Cycleave Method and Treatment Outcome with Daclatasvir and Asunaprevir for Chronic Hepatitis C Genotype 1

BACKGROUND: The aim of this study was to evaluate the efficacy of daclatasvir plus asunaprevir therapy in patients infected with hepatitis C virus and determine its relevance to resistant variants. METHODS: A total of 629 consecutive patients infected with hepatitis C virus genotype 1 were assessed....

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Publicado no:PLoS One
Main Authors: Ide, Tatsuya, Eguchi, Yuichiro, Harada, Masaru, Ishii, Kunihide, Morita, Masaru, Morita, Yasuyo, Sugiyama, Gen, Fukushima, Hirofumi, Yano, Yoichi, Noguchi, Kazunori, Nakamura, Hiroki, Hisatomi, Junjiro, Kumemura, Hiroto, Shirachi, Miki, Iwane, Shinji, Okada, Michiaki, Honma, Yuichi, Arinaga-Hino, Teruko, Miyajima, Ichiro, Ogata, Kei, Kuwahara, Reiichiro, Amano, Keisuke, Kawaguchi, Toshihiro, Kuromatsu, Ryoko, Torimura, Takuji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042440/
https://ncbi.nlm.nih.gov/pubmed/27684567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163884
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