ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice

BACKGROUND & AIMS: Defects in Paneth cell (PC) function are associated with microbial dysbiosis and intestinal inflammation. PC granules contain antimicrobial peptides, cytokines, and substantial stores of zinc (Zn). We hypothesized that Zn, transported into the granule through the Zn transporte...

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Detalles Bibliográficos
Publicado en:Cell Mol Gastroenterol Hepatol
Main Authors: Podany, Abigail B., Wright, Justin, Lamendella, Regina, Soybel, David I., Kelleher, Shannon L.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042355/
https://ncbi.nlm.nih.gov/pubmed/28174721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.12.006
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