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Targeting CD30 Using Brentuximab Vedotin in the Treatment of Hodgkin Lymphoma
The expression of CD30 receptors is one of the defining characteristics of the malignant Reed-Sternberg cells of Hodgkin lymphoma. CD30 is rarely expressed by normal cells, and is rapidly internalized, making it an ideal therapeutic target for monoclonal antibodies and for antibody-drug conjugates (...
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| 發表在: | Cancer J |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5042201/ https://ncbi.nlm.nih.gov/pubmed/26841013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PPO.0000000000000168 |
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