A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density

SynGAP is a Ras/Rap GTPase-activating protein (GAP) that is a major constituent of postsynaptic densities (PSDs) from mammalian forebrain. Its α1 isoform binds to all three PDZ (PSD-95, Discs-large, ZO-1) domains of PSD-95, the principal PSD scaffold, and can occupy as many as 15% of these PDZ domai...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Walkup, Ward G, Mastro, Tara L, Schenker, Leslie T, Vielmetter, Jost, Hu, Rebecca, Iancu, Ariella, Reghunathan, Meera, Bannon, Barry Dylan, Kennedy, Mary B
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040590/
https://ncbi.nlm.nih.gov/pubmed/27623146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16813
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