An Amphotericin B Derivative Equally Potent to Amphotericin B and with Increased Safety

Amphotericin B is the most potent antimycotic known to date. However due to its large collateral toxicity, its use, although long standing, had been limited. Many attempts have been made to produce derivatives with reduced collateral damage. The molecular mechanism of polyene has also been closely s...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Antillón, Armando, de Vries, Alexander H., Espinosa-Caballero, Marcel, Falcón-González, José Marcos, Flores Romero, David, González–Damián, Javier, Jiménez-Montejo, Fabiola Eloísa, León-Buitimea, Angel, López-Ortiz, Manuel, Magaña, Ricardo, Marrink, Siewert J., Morales-Nava, Rosmarbel, Periole, Xavier, Reyes-Esparza, Jorge, Rodríguez Lozada, Josué, Santiago-Angelino, Tania Minerva, Vargas González, María Cristina, Regla, Ignacio, Carrillo-Tripp, Mauricio, Fernández-Zertuche, Mario, Rodríguez-Fragoso, Lourdes, Ortega-Blake, Iván
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040443/
https://ncbi.nlm.nih.gov/pubmed/27683101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162171
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