Reduced neuronal size and mTOR pathway activity in the Mecp2 A140V Rett syndrome mouse model

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutation in the X-linked MECP2 gene, encoding methyl-CpG-binding protein 2. We have created a mouse model ( Mecp2 A140V “knock-in” mutant) expressing the recurrent human MECP2 A140V mutation linked to an X-linked mental retardation/Rett...

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Bibliographic Details
Published in:F1000Res
Main Authors: Rangasamy, Sampathkumar, Olfers, Shannon, Gerald, Brittany, Hilbert, Alex, Svejda, Sean, Narayanan, Vinodh
Format: Artigo
Language:Inglês
Published: F1000Research 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040159/
https://ncbi.nlm.nih.gov/pubmed/27781091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.8156.1
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