Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells

Background: Hierridin B was isolated from a marine cyanobacterium Cyanobium sp. strain and induced cytotoxicity selectively in HT-29 adenocarcinoma cells. The underlying molecular mechanism was not yet elucidated. Methods: HT-29 cells were exposed to the IC(50) concentration of hierridin B (100.2 μM...

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Udgivet i:Mar Drugs
Main Authors: Freitas, Sara, Martins, Rosário, Costa, Margarida, Leão, Pedro N., Vitorino, Rui, Vasconcelos, Vitor, Urbatzka, Ralph
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039529/
https://ncbi.nlm.nih.gov/pubmed/27589771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14090158
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