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Convergent Synthesis of Two Fluorescent Ebselen-Coumarin Heterodimers

The organo-seleniumdrug ebselen exhibits a wide range of pharmacological effects that are predominantly due to its interference with redox systems catalyzed by seleno enzymes, e.g., glutathione peroxidase and thioredoxin reductase. Moreover, ebselen can covalently interact with thiol groups of sever...

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Publicado en:Pharmaceuticals (Basel)
Main Authors: Küppers, Jim, Schulz-Fincke, Anna Christina, Palus, Jerzy, Giurg, Mirosław, Skarżewski, Jacek, Gütschow, Michael
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039496/
https://ncbi.nlm.nih.gov/pubmed/27399725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph9030043
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