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Gel-Entrapped Staphylococcus aureus Bacteria as Models of Biofilm Infection Exhibit Growth in Dense Aggregates, Oxygen Limitation, Antibiotic Tolerance, and Heterogeneous Gene Expression

An experimental model that mimicked the structure and characteristics of in vivo biofilm infections, such as those occurring in the lung or in dermal wounds where no biomaterial surface is present, was developed. In these infections, microbial biofilm forms as cell aggregates interspersed in a layer...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Pabst, Breana, Pitts, Betsey, Lauchnor, Ellen, Stewart, Philip S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038234/
https://ncbi.nlm.nih.gov/pubmed/27503656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01336-16
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