Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes

Children at risk for type 1 diabetes can develop early insulin autoantibodies (IAAs). Many, but not all, of these children subsequently develop multiple islet autoantibodies and diabetes. To determine whether disease progression is reflected by autoantibody maturity, IAA affinity was measured by com...

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Bibliographic Details
Main Authors: Achenbach, Peter, Koczwara, Kerstin, Knopff, Annette, Naserke, Heike, Ziegler, Anette-G., Bonifacio, Ezio
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC503771/
https://ncbi.nlm.nih.gov/pubmed/15314696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421307
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