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Intra-Peritoneal Administration of Mitochondrial DNA Provokes Acute Lung Injury and Systemic Inflammation via Toll-Like Receptor 9

The pathogenesis of sepsis is complex. Mitochondrial dysfunction, which is responsible for energy metabolism, intrinsic apoptotic pathway, oxidative stress, and systemic inflammatory responses, is closely related with severe sepsis induced death. Mitochondria DNA (mtDNA) contain un-methylated cytosi...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Zhang, Lemeng, Deng, Songyun, Zhao, Shuangping, Ai, Yuhang, Zhang, Lina, Pan, Pinhua, Su, Xiaoli, Tan, Hongyi, Wu, Dongdong
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037704/
https://ncbi.nlm.nih.gov/pubmed/27589725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17091425
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