MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression

Chondrocyte hypertrophy, regulated by Runt-related transcription factor 2 (RUNX2) and matrix metalloproteinase 13 (MMP13), is a crucial step in cartilage degeneration and osteoarthritis (OA) pathogenesis. We previously demonstrated that microRNA-381 (miR-381) promotes MMP13 expression during chondro...

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Pubblicato in:Int J Mol Sci
Autori principali: Chen, Weishen, Sheng, Puyi, Huang, Zhiyu, Meng, Fangang, Kang, Yan, Huang, Guangxin, Zhang, Zhiqi, Liao, Weiming, Zhang, Ziji
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037657/
https://ncbi.nlm.nih.gov/pubmed/27563877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17091377
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