TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways

BACKGROUND: Transducin-like enhancer of Split3 (TLE3) serves as a transcriptional corepressor during cell differentiation and shows multiple roles in different kinds of cancers. Recently, TLE3 together with many other genes involved in Wnt/β-catenin pathway were detected hyper-methylated in colorect...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Yang, Run-Wei, Zeng, Ying-Yue, Wei, Wen-Ting, Cui, Yan-Mei, Sun, Hui-Ying, Cai, Yue-Long, Nian, Xin-Xin, Hu, Yun-Teng, Quan, Yu-Ping, Jiang, Sheng-Lu, Wang, Meng, Zhao, Ya-Li, Qiu, Jun-Feng, Li, Ming-Xuan, Zhang, Jia-Huan, He, Mei-Rong, Liang, Li, Ding, Yan-Qing, Liao, Wen-Ting
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037636/
https://ncbi.nlm.nih.gov/pubmed/27669982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0426-8
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