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Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis
Clonally expanded populations of B cells carrying somatic mutations of Ig variable (V) region genes have been detected in the CNS of subjects with multiple sclerosis (MS), suggesting that a process of B cell affinity maturation with ensuing production of potentially pathogenic autoantibodies may occ...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC503741/ https://ncbi.nlm.nih.gov/pubmed/15263096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402455101 |
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