VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses

The integrin α4β1 (VLA-4) not only mediates the adhesion and transendothelial migration of leukocytes, but also provides costimulatory signals that contribute to the activation of T lymphocytes. However, the behavior of α4β1 during the formation of the immune synapse is currently unknown. Here, we s...

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Bibliografiske detaljer
Main Authors: Mittelbrunn, María, Molina, Ana, Escribese, María M., Yáñez-Mó, María, Escudero, Ester, Ursa, Ángeles, Tejedor, Reyes, Mampaso, Francisco, Sánchez-Madrid, Francisco
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC503740/
https://ncbi.nlm.nih.gov/pubmed/15263094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307927101
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