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90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus()()

β-Catenin is a major transducer of the Wnt signaling pathway, which is aberrantly expressed in colorectal and other cancers. Previously, we showed that β-catenin is downregulated by the 90K glycoprotein via ISGylation-dependent degradation. However, the further mechanisms of β-catenin degradation by...

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Vydáno v:Neoplasia
Hlavní autoři: Park, So-Yeon, Yoon, Somy, Kim, Hangun, Kim, Kyung Keun
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037265/
https://ncbi.nlm.nih.gov/pubmed/27668402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.08.006
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