Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome

BACKGROUND: Prolonged metabolic suppression in the brain is a well-characterized secondary pathology of both experimental and clinical traumatic brain injury (TBI). AMP-activated kinase (AMPK) acts as a cellular energy sensor that, when activated, regulates various metabolic and catabolic pathways t...

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Vydáno v:J Neurochem
Hlavní autoři: Hill, Julia L., Kobori, Nobuhide, Zhao, Jing, Rozas, Natalia S., Hylin, Michael J., Moore, Anthony N., Dash, Pramod K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037010/
https://ncbi.nlm.nih.gov/pubmed/27379837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13726
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