Characterization of immunogenic Neu5Gc in Bioprosthetic Heart Valves

BACKGROUND: The two common sialic acid (Sia) in mammals are N-Acetylneuraminic acid (Neu5Ac) and its hydroxylated form N-Glycolylneuraminic acid (Neu5Gc). Unlike most mammals, humans cannot synthesize Neu5Gc that is considered foreign and recognized by circulating antibodies. Thus, Neu5Gc is a poten...

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Published in:Xenotransplantation
Main Authors: Reuven, Eliran Moshe, Ben-Arye, Shani Leviatan, Marshanski, Tal, Breimer, Michael E., Yu, Hai, Fellah-Hebia, Imen, Roussel, Jean-Christian, Costa, Cristina, Galiñanes, Manuel, Mañez, Rafael, Tourneau, Thierry Le, Soulillou, Jean-Paul, Cozzi, Emanuele, Chen, Xi, Padler-Karavani, Vered
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036590/
https://ncbi.nlm.nih.gov/pubmed/27610947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12260
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