Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

Despite over 20 years of clinical use, IL-2 has not fulfilled expectations as a safe and effective form of tumour immunotherapy. Expression of the high affinity IL-2Rα chain on regulatory T cells mitigates the anti-tumour immune response and its expression on vascular endothelium is responsible for...

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Pubblicato in:Nat Commun
Autori principali: Ghasemi, Reza, Lazear, Eric, Wang, Xiaoli, Arefanian, Saeed, Zheleznyak, Alexander, Carreno, Beatriz M., Higashikubo, Ryuji, Gelman, Andrew E., Kreisel, Daniel, Fremont, Daved H., Krupnick, Alexander Sasha
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036003/
https://ncbi.nlm.nih.gov/pubmed/27650575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12878
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