Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading

GABA acts as the major inhibitory neurotransmitter in the mammalian brain, shaping neuronal and circuit activity. For sustained synaptic transmission, synaptic vesicles (SVs) are required to be recycled and refilled with neurotransmitters using an H(+) electrochemical gradient. However, neither the...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Egashira, Yoshihiro, Takase, Miki, Watanabe, Shoji, Ishida, Junji, Fukamizu, Akiyoshi, Kaneko, Ryosuke, Yanagawa, Yuchio, Takamori, Shigeo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035854/
https://ncbi.nlm.nih.gov/pubmed/27601664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604527113
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