Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading

GABA acts as the major inhibitory neurotransmitter in the mammalian brain, shaping neuronal and circuit activity. For sustained synaptic transmission, synaptic vesicles (SVs) are required to be recycled and refilled with neurotransmitters using an H(+) electrochemical gradient. However, neither the...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Egashira, Yoshihiro, Takase, Miki, Watanabe, Shoji, Ishida, Junji, Fukamizu, Akiyoshi, Kaneko, Ryosuke, Yanagawa, Yuchio, Takamori, Shigeo
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035854/
https://ncbi.nlm.nih.gov/pubmed/27601664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604527113
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