Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading

GABA acts as the major inhibitory neurotransmitter in the mammalian brain, shaping neuronal and circuit activity. For sustained synaptic transmission, synaptic vesicles (SVs) are required to be recycled and refilled with neurotransmitters using an H(+) electrochemical gradient. However, neither the...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Egashira, Yoshihiro, Takase, Miki, Watanabe, Shoji, Ishida, Junji, Fukamizu, Akiyoshi, Kaneko, Ryosuke, Yanagawa, Yuchio, Takamori, Shigeo
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035854/
https://ncbi.nlm.nih.gov/pubmed/27601664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604527113
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