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Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading
GABA acts as the major inhibitory neurotransmitter in the mammalian brain, shaping neuronal and circuit activity. For sustained synaptic transmission, synaptic vesicles (SVs) are required to be recycled and refilled with neurotransmitters using an H(+) electrochemical gradient. However, neither the...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035854/ https://ncbi.nlm.nih.gov/pubmed/27601664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604527113 |
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