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Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose

Type 1 diabetes occurs due to the autoimmune destruction of pancreatic β-cells in islets. Transplantation of islets is a promising option for the treatment of patients with type 1 diabetes that experience hypoglycemic unawareness despite maximal care, but the present shortage of donor islets hampers...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Saitoh, Issei, Sato, Masahiro, Soda, Miki, Inada, Emi, Iwase, Yoko, Murakami, Tomoya, Ohshima, Hayato, Hayasaki, Haruaki, Noguchi, Hirofumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035045/
https://ncbi.nlm.nih.gov/pubmed/27662374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163580
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