Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria

Background. Malaria remains a major cause of global mortality. Extracellular heme, released during malaria-induced hemolysis, mediates a number of pathogenic processes associated with vascular and organ injury. Hemopexin (hpx) facilitates the degradation of extracellular heme. In this study, we expl...

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Publicat a:J Infect Dis
Autors principals: Elphinstone, Robyn E., Conroy, Andrea L., Hawkes, Michael, Hermann, Laura, Namasopo, Sophie, Warren, H. Shaw, John, Chandy C., Liles, W. Conrad, Kain, Kevin C.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034960/
https://ncbi.nlm.nih.gov/pubmed/27515862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw357
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