WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα(12/13)

Frizzleds (FZDs) are unconventional G protein–coupled receptors that belong to the class Frizzled. They are bound and activated by the Wingless/Int-1 lipoglycoprotein (WNT) family of secreted lipoglycoproteins. To date, mechanisms of signal initiation and FZD–G protein coupling remain poorly underst...

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Publicat a:Mol Pharmacol
Autors principals: Arthofer, Elisa, Hot, Belma, Petersen, Julian, Strakova, Katerina, Jäger, Stefan, Grundmann, Manuel, Kostenis, Evi, Gutkind, J. Silvio, Schulte, Gunnar
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034691/
https://ncbi.nlm.nih.gov/pubmed/27458145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.104919
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