Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

OBJECTIVE: Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role of BCAA in the pathogenesis of insulin resistance and T2D remains unclear. METHODS: To identify pathways related to i...

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Détails bibliographiques
Publié dans:Mol Metab
Auteurs principaux: Lerin, Carles, Goldfine, Allison B., Boes, Tanner, Liu, Manway, Kasif, Simon, Dreyfuss, Jonathan M., De Sousa-Coelho, Ana Luisa, Daher, Grace, Manoli, Irini, Sysol, Justin R., Isganaitis, Elvira, Jessen, Niels, Goodyear, Laurie J., Beebe, Kirk, Gall, Walt, Venditti, Charles P., Patti, Mary-Elizabeth
Format: Artigo
Langue:Inglês
Publié: Elsevier 2016
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034611/
https://ncbi.nlm.nih.gov/pubmed/27689005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.08.001
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