Novel regional age-associated DNA methylation changes within human common disease-associated loci

BACKGROUND: Advancing age progressively impacts on risk and severity of chronic disease. It also modifies the epigenome, with changes in DNA methylation, due to both random drift and variation within specific functional loci. RESULTS: In a discovery set of 2238 peripheral-blood genome-wide DNA methy...

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Vydáno v:Genome Biol
Hlavní autoři: Bell, Christopher G., Xia, Yudong, Yuan, Wei, Gao, Fei, Ward, Kirsten, Roos, Leonie, Mangino, Massimo, Hysi, Pirro G., Bell, Jordana, Wang, Jun, Spector, Timothy D.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034469/
https://ncbi.nlm.nih.gov/pubmed/27663977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1051-8
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