Is radiographic progression in modern rheumatoid arthritis trials still a robust outcome? Experience from tofacitinib clinical trials

BACKGROUND: The detection of statistically significant reductions in radiographic progression during clinical studies in patients with rheumatoid arthritis (RA) has become increasingly difficult over the past decade due to early-escape study designs and declining rates of progression in control-grou...

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Pubblicato in:Arthritis Res Ther
Autori principali: Landewé, Robert B. M., Connell, Carol A., Bradley, John D., Wilkinson, Bethanie, Gruben, David, Strengholt, Sander, van der Heijde, Désirée
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034418/
https://ncbi.nlm.nih.gov/pubmed/27663201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1106-y
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