A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH(2), induces protease release from mast cells: role in TNF degradation

BACKGROUND: Mast cell (MC)-derived serine proteases have been implicated in a variety of inflammatory processes. We have previously shown that rat peritoneal MC (PMC) express mRNA for protease activated receptor 2 (PAR-2), a G-coupled receptor activated by trypsin-like proteases. Recent evidence als...

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Detalhes bibliográficos
Main Authors: Alshurafa, Hashem N, Stenton, Grant R, Wallace, John L, Hollenberg, Morley D, Dean Befus, A, Vliagoftis, Harissios
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC503387/
https://ncbi.nlm.nih.gov/pubmed/15265236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-4-12
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