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Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery
The intrathecal (IT) dosing route offers a seemingly obvious solution for delivering drugs directly to the central nervous system. However, gaps in understanding drug molecule behavior within the anatomically and kinetically unique environment of the mammalian IT space have impeded the establishment...
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| Publié dans: | JCI Insight |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5033865/ https://ncbi.nlm.nih.gov/pubmed/27699254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85311 |
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