Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell–derived ADAM9

Metastatic dissemination of cancer cells, which accounts for 90% of cancer mortality, is the ultimate hallmark of malignancy. Growing evidence suggests that blood platelets have a predominant role in tumor metastasis; however, the molecular mechanisms involved remain elusive. Here, we demonstrate th...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Mammadova-Bach, Elmina, Zigrino, Paola, Brucker, Camille, Bourdon, Catherine, Freund, Monique, De Arcangelis, Adèle, Abrams, Scott I., Orend, Gertaud, Gachet, Christian, Mangin, Pierre Henri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033851/
https://ncbi.nlm.nih.gov/pubmed/27699237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88245
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